We study the shrinking and separation properties (two notions well-known in descriptive set theory) for NP and coNP and show that under reasonable complexity-theoretic assumptions, both properties do not hold for NP and the shrinking property does not hold for coNP. In particular we obtain the following results.

1. NP ... more >>>

We give improved inapproximability results for some minimization problems in the second level of the Polynomial-Time Hierarchy. Extending previous work by Umans [Uma99], we show that several variants of DNF minimization are $\Sigma_2^p$-hard to approximate to within factors of $n^{1/3-\epsilon}$ and $n^{1/2-\epsilon}$ (where the previous results achieved $n^{1/4 - \epsilon}$), ... more >>>

In earlier work, we gave an oracle separating the relational versions of BQP and the polynomial hierarchy, and showed that an oracle separating the decision versions would follow from what we called the Generalized Linial-Nisan (GLN) Conjecture: that "almost k-wise independent" distributions are indistinguishable from the uniform distribution by constant-depth ... more >>>

We investigate the role of nondeterminism in Winfree's abstract Tile Assembly Model (aTAM), which was conceived to model artificial molecular self-assembling systems constructed from DNA. Designing tile systems that assemble shapes, due to the algorithmic richness of the aTAM, is a form of sophisticated "molecular programming". Of particular practical importance ... more >>>

We give new evidence that quantum computers -- moreover, rudimentary quantum computers built entirely out of linear-optical elements -- cannot be efficiently simulated by classical computers. In particular, we define a
model of computation in which identical photons are generated, sent through a linear-optical network, then nonadaptively measured to count ... more >>>